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Tobias Erlöv, MSc, PhD. Photo.

Tobias Erlöv

Researcher

Tobias Erlöv, MSc, PhD. Photo.

Comparison of photoacoustic imaging and histopathological examination in determining the dimensions of 52 human melanomas and nevi ex vivo : Biomedical Optics Express

Author

  • Jenny Hult
  • Aboma Merdasa
  • Agnes Pekar-Lukacs
  • Magne Tordengren Stridh
  • Azin Khodaverdi
  • John Albinsson
  • Bodil Gesslein
  • Ulf Dahlstrand
  • Linn Engqvist
  • Yousef Hamid
  • Douglas Larsson Albèr
  • Bertil Persson
  • Tobias Erlöv
  • Rafi Sheikh
  • Magnus Cinthio
  • Malin Malmsjö
Show all

Summary, in English

Surgical excision followed by histopathological examination is the gold standard for the diagnosis and staging of melanoma. Reoperations and unnecessary removal of healthy tissue could be reduced if non-invasive imaging techniques were available for presurgical tumor delineation. However, no technique has gained widespread clinical use to date due to shallow imaging depth or the absence of functional imaging capability. Photoacoustic (PA) imaging is a novel technology that combines the strengths of optical and ultrasound imaging to reveal the molecular composition of tissue at high resolution. Encouraging results have been obtained from previous animal and human studies on melanoma, but there is still a lack of clinical data. This is the largest study of its kind to date, including 52 melanomas and nevi. 3D multiwavelength PA scanning was performed ex vivo, using 59 excitation wavelengths from 680 nm to 970 nm. Spectral unmixing over this broad wavelength range, accounting for the absorption of several tissue chromophores, provided excellent contrast between healthy tissue and tumor. Combining the results of spectral analysis with spatially resolved information provided a map of the tumor borders in greater detail than previously reported. The tumor dimensions determined with PA imaging were strongly correlated with those determined by histopathological examination for both melanomas and nevi.

Department/s

  • Ophthalmology, Lund
  • Ophthalmology Imaging Research Group
  • Department of Biomedical Engineering
  • LUCC: Lund University Cancer Centre
  • LUSCaR- Lund University Skin Cancer Research group
  • Dermatology and Venereology (Lund)

Publishing year

2021

Language

English

Pages

4097-4114

Publication/Series

Biomedical Optics Express

Volume

12

Issue

7

Document type

Journal article

Publisher

Optical Society of America

Topic

  • Ophthalmology
  • Cancer and Oncology
  • Dermatology and Venereal Diseases

Keywords

  • Functional imaging
  • Imaging techniques
  • Magnetic resonance imaging
  • Optical coherence tomography
  • Photoacoustic imaging
  • Positron emission tomography

Status

Published

Research group

  • Ophthalmology Imaging Research Group
  • LUSCaR- Lund University Skin Cancer Research group

ISBN/ISSN/Other

  • ISSN: 2156-7085