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Multiscale models for T-cell commitment

T-cell development serves as a powerful model for studying lineage commitment from multipotent progenitors. To investigate the timing and inheritance of T-cell fate decisions, multi-scale agent-based models are designed, optimized, and validated using single-cell molecular and imaging data from the Rothenberg lab at Caltech.

Multiscale models for T-cell commitment. Image of method overview.

 

Selected publications

Olariu V., Yui M.A., Krupinski P., Andersson E., Rothenberg E.V., Peterson C., Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment, Cell Reports, Volume 34, Issue 2, 108622

Andersson E., Rothenberg E.V. , Peterson C., Olariu V., T-cell commitment inheritance – an agent-based multi-scale model, bioRxiv 2023.10.18.562905

Project participants

Professor Ellen Rothenberg, MSc, PhD. Photo
Professor Ellen Rothenberg, MSc, PhD.
Post Retirement Professor Carsten Peterson, MSc, PhD. Photo.
Post Retirement Professor Carsten Peterson, MSc, PhD
Emil Andersson, MSc, PhD. Photo.
Emil Andersson, MSc, PhD
Senior Lecturer Victor Olariu, MSc, PhD. Photo
Senior Lecturer Victor Olariu, MSc, PhD
Page manager: john [dot] albinsson [at] med [dot] lu [dot] se | 27 Feb 2025