Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

3D modelling of the neural tube development

Gaining insights into neural tube regulation and optimizing protocols for dopaminergic neuron generation require a novel framework integrating gene circuit models with morphogen inputs. Optimized using single-cell data from human embryonic stem cell differentiation (provided by Kirkeby lab, Copenhagen University, Parmar lab, Lund University), these models will capture rostro-caudal and dorso-ventral patterning (ref. Brambach). A multi-scale 3D model then predicts key molecular mechanisms in vivo, such as isthmic organizer formation, where comprehensive data is lacking.