3D modelling of the neural tube development
Gaining insights into neural tube regulation and optimizing protocols for dopaminergic neuron generation require a novel framework integrating gene circuit models with morphogen inputs. Optimized using single-cell data from human embryonic stem cell differentiation (provided by Kirkeby lab, Copenhagen University, Parmar lab, Lund University), these models will capture rostro-caudal and dorso-ventral patterning (ref. Brambach). A multi-scale 3D model then predicts key molecular mechanisms in vivo, such as isthmic organizer formation, where comprehensive data is lacking.
Selected publications