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3D modelling of the neural tube development

Gaining insights into neural tube regulation and optimizing protocols for dopaminergic neuron generation require a novel framework integrating gene circuit models with morphogen inputs. Optimized using single-cell data from human embryonic stem cell differentiation (provided by Kirkeby lab, Copenhagen University, Parmar lab, Lund University), these models will capture rostro-caudal and dorso-ventral patterning (ref. Brambach). A multi-scale 3D model then predicts key molecular mechanisms in vivo, such as isthmic organizer formation, where comprehensive data is lacking.

3D modelling of the neural tube development. Image of method overview.

 

Selected publications

Merlevede, A., Legault, E.M., Drugge, V., BarkerR.A., Drouin-Ouellet J., Olariu V. A quantitative model of cellular decision making in direct neuronal reprogramming. Sci Rep 11, 1514 (2021)

Project participants

Alexander Degener, MSc, PhD-student. Photo
Alexander Degener, MSc, PhD-student
Associate professor Agnete Kirkeby, MSc, PhD. Photo
Associate professor Agnete Kirkeby, MSc, PhD
Senior Lecturer Victor Olariu, MSc, PhD. Photo
Senior Lecturer Victor Olariu, MSc, PhD