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Tobias Erlöv, MSc, PhD. Photo.

Tobias Erlöv

Researcher

Tobias Erlöv, MSc, PhD. Photo.

Regional motion correction for in vivo photoacoustic imaging in humans using interleaved ultrasound images

Author

  • Tobias Erlöv
  • Rafi Sheikh
  • Ulf Dahlstrand
  • John Albinsson
  • Malin Malmsjö
  • Magnus Cinthio

Summary, in Swedish

In translation from preclinical to clinical studies using photoacoustic imaging, motion artifacts represent a major issue. In this study the feasibility of an in-house algorithm, referred to as intensity phase tracking (IPT), for regional motion correction of in vivo human photoacoustic (PA) images was demonstrated. The algorithm converts intensity to phase-information and performs 2D phase-tracking on interleaved ultrasound images. The radial artery in eight healthy volunteers was imaged using an ultra-high frequency photoacoustic system. PA images were motion corrected and evaluated based on PA image similarities. Both controlled measurements using a computerized stepping motor and free-hand measurements were evaluated. The results of the controlled measurements show that the tracking corresponded to 97 ± 6% of the actual movement. Overall, the mean square error between PA images decreased by 52 ± 15% and by 43 ± 19% when correcting for controlled- and free-hand induced motions, respectively. The results show that the proposed algorithm could be used for motion correction in photoacoustic imaging in humans.

Department/s

  • Department of Biomedical Engineering
  • Ophthalmology Imaging Research Group
  • Ophthalmology, Lund

Publishing year

2021-05-12

Language

Swedish

Pages

3312-3322

Publication/Series

Biomedical Optics Express

Volume

12

Issue

6

Document type

Journal article

Publisher

Optical Society of America

Topic

  • Radiology, Nuclear Medicine and Medical Imaging
  • Ophthalmology

Keywords

  • Image quality
  • In vivo imaging
  • Optical flow
  • Photoacoustic imaging
  • Spatial resolution
  • Spectral imaging

Status

Published

Research group

  • Ophthalmology Imaging Research Group

ISBN/ISSN/Other

  • ISSN: 2156-7085