The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Sophia Zackrisson, MD, PhD. Photo.

Sophia Zackrisson

Manager

Sophia Zackrisson, MD, PhD. Photo.

Development and evaluation of a method for tumor growth simulation in virtual clinical trials of breast cancer screening

Author

  • Hanna Tomic
  • Anna Bjerkén
  • Gustav Hellgren
  • Kristin Johnson
  • Daniel Förnvik
  • Sophia Zackrisson
  • Anders Tingberg
  • Magnus Dustler
  • Predrag R. Bakic

Summary, in English

Purpose: Image-based analysis of breast tumor growth rate may optimize breast cancer screening and diagnosis by suggesting optimal screening intervals and guide the clinical discussion regarding personalized screening based on tumor aggressiveness. Simulation-based virtual clinical trials (VCTs) can be used to evaluate and optimize medical imaging systems and design clinical trials. This study aimed to simulate tumor growth over multiple screening rounds. Approach: This study evaluates a preliminary method for simulating tumor growth. Clinical data on tumor volume doubling time (TVDT) was used to fit a probability distribution ("clinical fit") of TVDTs. Simulated tumors with TVDTs sampled from the clinical fit were inserted into 30 virtual breasts ("simulated cohort") and used to simulate mammograms. Based on the TVDT, two successive screening rounds were simulated for each virtual breast. TVDTs from clinical and simulated mammograms were compared. Tumor sizes in the simulated mammograms were measured by a radiologist in three repeated sessions to estimate TVDT. Results: The mean TVDT was 297 days (standard deviation, SD, 169 days) in the clinical fit and 322 days (SD, 217 days) in the simulated cohort. The mean estimated TVDT was 340 days (SD, 287 days). No significant difference was found between the estimated TVDTs from simulated mammograms and clinical TVDT values (p > 0.5). No significant difference (p > 0.05) was observed in the reproducibility of the tumor size measurements between the two screening rounds. Conclusions: The proposed method for tumor growth simulation has demonstrated close agreement with clinical results, supporting potential use in VCTs of temporal breast imaging.

Department/s

  • LUCC: Lund University Cancer Centre
  • Radiology Diagnostics, Malmö
  • Medical Radiation Physics, Malmö
  • LTH Profile Area: Photon Science and Technology
  • EpiHealth: Epidemiology for Health

Publishing year

2022-05-01

Language

English

Publication/Series

Journal of Medical Imaging

Volume

9

Issue

3

Document type

Journal article

Publisher

SPIE

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • digital mammography
  • simulation
  • tumor growth
  • tumor volume doubling time
  • virtual clinical trials

Status

Published

Research group

  • Radiology Diagnostics, Malmö
  • Medical Radiation Physics, Malmö

ISBN/ISSN/Other

  • ISSN: 2329-4302