
Rafi Sheikh
Research project participant

Photoacoustic imaging for three-dimensional visualization and delineation of basal cell carcinoma in patients
Author
Summary, in English
Background: Photoacoustic (PA) imaging is an emerging non-invasive biomedical imaging modality that could potentially be used to determine the borders of basal cell carcinomas (BCC) preoperatively in order to reduce the need for repeated surgery.
Methods: Two- and three-dimensional PA images were obtained by scanning BCCs using 59 wavelengths in the range 680-970 nm. Spectral unmixing was performed to visualize the tumor tissue distribution. Spectral signatures from 38 BCCs and healthy tissue were compared ex vivo.
Results and discussion: The PA spectra could be used to differentiate between BCC and healthy tissue ex vivo (p < 0.05). Spectral unmixing provided visualization of the overall architecture of the lesion and its border.
Conclusion: PA imaging can be used to differentiate between BCC and healthy tissue and can potentially be used to delineate tumors prior to surgical excision.
Department/s
- Ophthalmology Imaging Research Group
- Ophthalmology, Lund
- Combustion Physics
- Chemical Physics
- Department of Biomedical Engineering
- Clinical and experimental lung transplantation
- NPWT technology
Publishing year
2020-06
Language
English
Publication/Series
Photoacoustics
Volume
18
Document type
Journal article
Publisher
Elsevier
Topic
- Ophthalmology
- Radiology, Nuclear Medicine and Medical Imaging
Status
Published
Research group
- Ophthalmology Imaging Research Group
- Clinical and experimental lung transplantation
- NPWT technology
ISBN/ISSN/Other
- ISSN: 2213-5979