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University Lecturer Nina Reistad MSc, PhD

Nina Reistad

Senior lecturer

University Lecturer Nina Reistad MSc, PhD

Photoacoustic imaging of the spatial distribution of oxygen saturation in an ischemia-reperfusion model in humans

Author

  • Aboma Merdasa
  • Josefine Bunke
  • Magdalena Naumovska
  • John Albinsson
  • Tobias Erlöv
  • Magnus Cinthio
  • Nina Reistad
  • Rafi Sheikh
  • Malin Malmsjö

Summary, in English

Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the advantages of optical and ultrasound imaging to produce hyperspectral images of the tissue. The feasibility of measuring oxygen saturation (sO2) with PAI has been demonstrated pre-clinically, but has limited use in humans under conditions of ischemia and reperfusion. As an important step towards making PAI clinically available, we present a study in which PAI was used to estimate the spatial distribution of sO2 in vivo during and after occlusion of the finger of eight healthy volunteers. The results were compared with a commercial oxygen saturation monitor based on diffuse reflectance spectroscopy. We here describe the capability of PAI to provide spatially resolved picture of the evolution of sO2 during ischemia following vascular occlusion of a finger, demonstrating the clinical viability of PAI as a non-invasive diagnostic tool for diseases indicated by impaired microvascularization.

Department/s

  • Ophthalmology, Lund
  • Ophthalmology Imaging Research Group
  • Combustion Physics
  • Chemical Physics
  • Department of Biomedical Engineering
  • Centre for Environmental and Climate Science (CEC)
  • Atomic Physics
  • Department of Physics
  • Clinical and experimental lung transplantation
  • NPWT technology

Publishing year

2021

Language

English

Pages

2484-2495

Publication/Series

Biomedical Optics Express

Volume

12

Issue

4

Document type

Journal article

Publisher

Optical Society of America

Topic

  • Medical Biotechnology

Status

Published

Research group

  • Ophthalmology Imaging Research Group
  • Clinical and experimental lung transplantation
  • NPWT technology

ISBN/ISSN/Other

  • ISSN: 2156-7085