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University Lecturer Nina Reistad MSc, PhD

Nina Reistad

Senior lecturer

University Lecturer Nina Reistad MSc, PhD

Photoacoustic imaging for the monitoring of local changes in oxygen saturation following an adrenaline injection in human forearm skin

Author

  • Josefine Bunke
  • Aboma Merdasa
  • Rafi Sheikh
  • John Albinsson
  • Tobias Erlöv
  • Bodil Gesslein
  • Magnus Cinthio
  • Nina Reistad
  • Malin Malmsjö

Summary, in English

Clinical monitoring of blood oxygen saturation (sO2) is traditionally performed using optical techniques, such as pulse oximetry and diffuse reflectance spectroscopy (DRS), which lack spatial resolution. Photoacoustic imaging (PAI) is a rapidly developing biomedical imaging technique that is superior to previous techniques in that it combines optical excitation and acoustic detection, providing a map of chromophore distribution in the tissue. Hitherto, PAI has primarily been used in preclinical studies, and only a few studies have been performed in patients. Its ability to measure sO2 with spatial resolution during local vasoconstriction after adrenaline injection has not yet been investigated. Using PAI and spectral unmixing we characterize the heterogeneous change in sO2 after injecting a local anesthetic containing adrenaline into the dermis on the forearm of seven healthy subjects. In comparison to results obtained using DRS, we highlight contrasting results obtained between the two methods arising due to the so-called ‘window effect’ caused by a reduced blood flow in the superficial vascular plexus. The results demonstrate the importance of spatially resolving sO2 and the ability of PAI to assess the tissue composition in different layers of the skin.

Department/s

  • Ophthalmology Imaging Research Group
  • Ophthalmology, Lund
  • Combustion Physics
  • Department of Biomedical Engineering
  • Centre for Environmental and Climate Science (CEC)
  • Atomic Physics
  • Department of Physics

Publishing year

2021-07-01

Language

English

Pages

4084-4096

Publication/Series

Biomedical Optics Express

Volume

12

Issue

7

Document type

Journal article

Publisher

Optical Society of America

Topic

  • Medical Biotechnology

Keywords

  • Diffuse optical tomography
  • Diffuse reflectance spectroscopy
  • Imaging techniques
  • Magnetic resonance imaging
  • Medical imaging
  • Speckle imaging

Status

Published

Research group

  • Ophthalmology Imaging Research Group

ISBN/ISSN/Other

  • ISSN: 2156-7085