Diffuse reflectance spectroscopy of liver tissue

Summary, in English

Diffuse reflectance spectroscopy (DRS) with a fiber-optic contact probe is a cost-effective, rapid, and non-invasive optical method used to extract diagnosis information of tissue. By combining commercially available VIS- and NIR-spectrometers with various fiber-optic contact-probes, we have access to the full wavelength range from around 400 to 1600 nm. Using this flexible and portable spectroscopy system, we have acquired ex-vivo DRS-spectra from murine, porcine, and human liver tissue. For extracting the tissue optical properties from the measured spectra, we have employed and compared predictions from two models for light propagation in tissue, diffusion theory model (DT) and Monte Carlo simulations (MC).

The focus in this work is on the capacity of this DRS-technique in discriminating metastatic tumor tissue from normal liver tissue as well as in assessing and characterizing damage to non-malignant liver tissue induced by preoperative chemotherapy for colorectal liver metastases.

• Author: Nina Reistad; Jan Nilsson; Oskar Vilhelmsson Timmermand; Christian Sturesson; Stefan Andersson-Engels
• Department/s: Atomic Physics; Surgery (Lund); Departments at LTH
• Publishing year: 2015
• Language: English
• Pages: 95314-95314
• Publication/Series: [Host publication title missing]
• Volume: 9531
• Links: http://dx.doi.org/10.1117/12.2181008
• Document type: Conference paper
• Publisher: SPIE
• Topic: Applied Mechanics; Atom and Molecular Physics and Optics
• Keywords: Diffuse reflectance spectroscopy; liver tissue; optical properties.
• Conference name: SPIE Biophotonics South America 2015
• Conference date: 2015-05-23 - 2015-05-25
• Conference place: Rio de Janeiro, Brazil
• Status: Published
• Research group: Biophotonics
• ISBN/ISSN/Other: ISSN: 0277-786X; ISSN: 1996-756X