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University Lecturer Nina Reistad MSc, PhD

Nina Reistad

Senior lecturer

University Lecturer Nina Reistad MSc, PhD

Identification of tumor margins using diffuse reflectance spectroscopy with an extended-wavelength spectrum in a porcine model

Author

  • U Dahlstrand
  • R Sheikh
  • C D Nguyen
  • J Hult
  • N Reistad
  • M Malmsjö

Summary, in English

OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.

MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were made on 13 pigmented skin lesions and non-pigmented skin, as a reference. The hand-held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS-defined border and the histological border was measured by 3 independent examiners.

RESULTS: The median difference between the EWDRS-defined border and the histological border was 70 μm toward the pigmented tissue (range: -579 to 538 μm). A Pearson correlation coefficient of .95 was obtained for the examiners.

CONCLUSIONS: Extended-wavelength diffuse reflectance spectroscopy can be used in vivo to delineate the border of pigmented skin lesions in a porcine model with high accuracy, indicating that it may be a useful tool for non-invasive tumor margin delineation in the future.

Department/s

  • Ophthalmology Imaging Research Group
  • Ophthalmology, Lund
  • Atomic Physics
  • National Resource Centre for Physics Education
  • Clinical and experimental lung transplantation
  • NPWT technology

Publishing year

2018

Language

English

Pages

667-671

Publication/Series

Skin Research and Technology

Volume

24

Issue

4

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Ophthalmology
  • Biomedical Laboratory Science/Technology

Keywords

  • Journal Article

Status

Published

Research group

  • Ophthalmology Imaging Research Group
  • Clinical and experimental lung transplantation
  • NPWT technology

ISBN/ISSN/Other

  • ISSN: 0909-752X