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Professor Malin Malmsjö, MD, PhD. Photo.

Malin Malmsjö

Professor

Professor Malin Malmsjö, MD, PhD. Photo.

Increased ET(A) and ET(B) receptor contraction in the left internal mammary artery from patients with hypertension.

Author

  • David Nilsson
  • Angelica Wackenfors
  • Lotta Gustafsson
  • Lars Edvinsson
  • Per Paulsson
  • Richard Ingemansson
  • Malin Malmsjö

Summary, in English

Patients with hypertension have an increased activity in the endothelin system and an increased vascular tone, which predisposes them to target organ damage. In the present study, in vitro pharmacology, real-time PCR and immunofluorescence techniques were used to show enhanced endothelin type A (ETA) and type B (ETB) receptor contraction and expression in the left internal mammary artery from patients with hypertension as compared to normotensive patients. These receptors may be important in the pathophysiology of hypertension.

Department/s

  • Medicine, Lund
  • Ophthalmology, Lund
  • Thoracic Surgery

Publishing year

2008

Language

English

Pages

226-229

Publication/Series

Journal of Human Hypertension

Volume

22

Issue

3

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

ISBN/ISSN/Other

  • ISSN: 1476-5527