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Professor Malin Malmsjö, MD, PhD. Photo.

Malin Malmsjö

Professor

Professor Malin Malmsjö, MD, PhD. Photo.

Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases : A double-blinded placebo-controlled study

Author

  • Martine Wlosinska
  • Ann Christin Nilsson
  • Joanna Hlebowicz
  • Malin Malmsjö
  • Mohammed Fakhro
  • Sandra Lindstedt

Summary, in English

Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse–Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points. The mean percent change between the two time points 0 and 12 months was 102, 64 (174, 15)% change for AGE and 78, 62 (107, 92)% change for the placebo group (F[1, 120] = 5. 95, P < 0.016), 12 months of AGE increases the microcirculation in patients with an increased risk for cardiovascular events estimated using the Framingham risk score. Increased microcirculation could hypothetically facilitate wound healing.

Department/s

  • Thoracic Surgery
  • Cardiology
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Ophthalmology, Lund
  • Ophthalmology Imaging Research Group

Publishing year

2019

Language

English

Pages

1487-1493

Publication/Series

International Wound Journal

Volume

16

Issue

6

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • aged garlic extract
  • atherosclerosis
  • cutaneous microcirculation
  • double blinded
  • laser Doppler velocimetry

Status

Published

Project

  • Microvascular blood flow measurements with laser speckle contranst imaging in skin, lung and heart

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Ophthalmology Imaging Research Group

ISBN/ISSN/Other

  • ISSN: 1742-4801