Effects of vacuum-assisted closure on central hemodynamics in a sternotomy wound model

Summary, in English

Several authors have reported promising results with vacuum-assisted closure therapy in poststernotomy mediastinitis. The aim of this study was to investigate the hemodynamic outcome following the application of six negative pressures on an open sternotomy wound. Six 70-kg pigs underwent median sternotomy followed by vacuum-assisted closure therapy. Six negative pressures (-50, -75, -100, -125, -150, and -175mmHg) were applied to each pig for 30min each while hemodynamic parameters were measured. An increase in cardiac output was observed at -75mmHg when compared to the other five pressures: -50mmHg (P<0.05; CI 0.12-1.13l/min), -100mmHg (P<0.001; CI 0.34-1.32l/min), -125mmHg (P<0.001; CI 0.51-1.52l/min), -150mmHg (P<0.001; CI 0.50-1.47l/min), and -175mmHg (P<0.05; CI 0.13-1.17l/min). A decrease in systemic vascular resistance was observed at -75mmHg when compared to -125mmHg (P<0.01; CI 108-552dyn.s/cm(5)) and -150mmHg (P<0.01; CI 90-543dyn.s/cm(5)), but not compared to the other pressures. No change (P=ns) was observed in heart frequency, mean arterial pressure or central venous pressure. Our data demonstrates that vacuum-assisted closure therapy of -50 to -175mmHg does not impair the central hemodynamics in a porcine sternotomy model.

• Author: Johan Sjögren; Ronny Gustafsson; Angelica Wackenfors; Malin Malmsjö; Lars Algotsson; Richard Ingemansson
• Department/s: Thoracic Surgery; Medicine, Lund; Anesthesiology and Intensive Care
• Publishing year: 2004
• Language: English
• Pages: 666-671
• Publication/Series: Interactive Cardiovascular and Thoracic Surgery
• Volume: 3
• Issue: 4
• Links: http://dx.doi.org/10.1016/j.icvts.2004.08.003
• Document type: Journal article
• Publisher: European Association of Cardio-Thoracic Surgery
• Topic: Cardiac and Cardiovascular Systems; Surgery
• Status: Published
• ISBN/ISSN/Other: ISSN: 1569-9285