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Professor Malin Malmsjö, MD, PhD. Photo.

Malin Malmsjö

Professor

Professor Malin Malmsjö, MD, PhD. Photo.

Negative-pressure wound therapy using gauze or open-cell polyurethane foam: similar early effects on pressure transduction and tissue contraction in an experimental porcine wound model.

Author

  • Malin Malmsjö
  • Richard Ingemansson
  • Robin Martin
  • Elizabeth Huddleston

Summary, in English

Negative-pressure wound therapy (NPWT), also known as topical negative-pressure therapy, is widely used to manage wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane foam, but increasing interest has been directed toward delivering NPWT via gauze. In the present study, the early effects of NPWT on pressure transduction and wound contraction were examined in wounds filled with either polyurethane foam or gauze. An experimental setup of a porcine wound model was used, in which the animals were anesthetized for 12-14 hours. Negative pressures between -50 and -175 mmHg were applied in -25 mmHg increments. Wound bed pressure was measured using a saline filled catheter sutured to the bottom of the wound. The contraction of the wound edges was also determined. The recordings were performed upon reaching steady state, which typically occurred within 1 minute. For both fillers, wound bed negative pressure increased linearly with delivered vacuum with little deviation from set pressure (correlation coefficient 0.99 in both cases). Similar tissue contraction was observed when using foam and gauze. The most prominent contraction was observed in the range of 0 to -50 mmHg with greater vacuum only producing minor further movement of the wound edge. In conclusion, the present experimental study shows that gauze and foam are equally effective at delivering negative pressure and creating mechanical deformation of the wound.

Department/s

  • Medicine, Lund
  • Thoracic Surgery

Publishing year

2009

Language

English

Pages

200-205

Publication/Series

Wound Repair and Regeneration

Volume

17

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Other Clinical Medicine
  • Cardiac and Cardiovascular Systems
  • Surgery

Status

Published

ISBN/ISSN/Other

  • ISSN: 1524-475X