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Magnus Cinthio, MSc, PhD. Photo.

Magnus Cinthio

Senior lecturer

Magnus Cinthio, MSc, PhD. Photo.

Profound Increase in Longitudinal Displacements of the Porcine Carotid Artery Wall Can Take Place Independently of Wall Shear Stress: A Continuation Report.

Author

  • Åsa Rydén Ahlgren
  • Stig Steen
  • Simon Segstedt
  • Tobias Erlöv
  • Kjell Lindström
  • Trygve Sjöberg
  • Hans W Persson
  • Stefano Ricci
  • Piero Tortoli
  • Magnus Cinthio

Summary, in English

The mechanisms underlying longitudinal displacements of the arterial wall, that is, displacements of the wall layers along the artery, and the resulting intramural shear strain remain largely unknown. We have already found that these displacements undergo profound changes in response to catecholamines. Wall shear stress, closely related to wall shear rate, represents the viscous drag exerted on the vessel wall by flowing blood. The aim of the work described here was to study possible relations between the wall shear rate and the longitudinal displacements. We investigated the carotid arteries of five anesthetized pigs in different hemodynamic situations using in-house developed non-invasive ultrasound techniques. The study protocol included administration of epinephrine, norepinephrine and β-blockade (metoprolol). No significant correlation between longitudinal displacement of the intima-media complex and wall shear rate was found. This result suggests that one or multiple pulsatile forces other than wall shear stress are also working along arteries, strongly influencing arterial wall behavior.

Department/s

  • Clinical Physiology and Nuclear Medicine, Malmö
  • Thoracic Surgery
  • Department of Biomedical Engineering

Publishing year

2015

Language

English

Pages

1342-1353

Publication/Series

Ultrasound in Medicine and Biology

Volume

41

Issue

5

Document type

Journal article

Publisher

Elsevier

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Research group

  • Clinical Physiology, Malmö

ISBN/ISSN/Other

  • ISSN: 0301-5629