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Magnus Cinthio, MSc, PhD. Photo.

Magnus Cinthio

Senior lecturer

Magnus Cinthio, MSc, PhD. Photo.

Combined Magnetomotive ultrasound, PET/CT, and MR imaging of (68)Ga-labelled superparamagnetic iron oxide nanoparticles in rat sentinel lymph nodes in vivo

Author

  • Maria Evertsson
  • Pontus Kjellman
  • Magnus Cinthio
  • Roger Andersson
  • Thuy A Tran
  • René In 'T Zandt
  • Gustav Grafström
  • Hanna Toftevall
  • Sarah Fredriksson
  • Christian Ingvar
  • Sven-Erik Strand
  • Tomas Jansson
Show all

Summary, in English

Current methods for intra-surgical guidance to localize metastases at cancer surgery are based on radioactive tracers that cause logistical challenges. We propose the use of a novel ultrasound-based method, magnetomotive ultrasound (MMUS) imaging that employ a nanoparticle-based contrast agent that also may be used for pre-operative PET/MRI imaging. Since MMUS is radiation free, this eliminates the dependence between pre- and intra-operative imaging and the radiation exposure for the surgical staff. This study investigates a hypothetical clinical scenario of pre-operative PET imaging, combined with intra-operative MMUS imaging, implemented in a sentinel lymph node (SLN) rat model. At one-hour post injection of (68)Ga-labelled magnetic nanoparticles, six animals were imaged with combined PET/CT. After two or four days, the same animals were imaged with MMUS. In addition, ex-vivo MRI was used to evaluate the amount of nanoparticles in each single SLN. All SLNs were detectable by PET. Four out of six SLNs could be detected with MMUS, and for these MMUS and MRI measurements were in close agreement. The MRI measurements revealed that the two SLNs undetectable with MMUS contained the lowest nanoparticle concentrations. This study shows that MMUS can complement standard pre-operative imaging by providing bedside real-time images with high spatial resolution.

Department/s

  • Department of Biomedical Engineering
  • Systemic Radiation Therapy Group
  • Lund University Bioimaging Center
  • Tumor microenvironment
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2017-07-06

Language

English

Publication/Series

Scientific Reports

Volume

7

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Radiology, Nuclear Medicine and Medical Imaging
  • Cancer and Oncology
  • Other Physics Topics

Keywords

  • Journal Article

Status

Published

Research group

  • Systemic Radiation Therapy Group

ISBN/ISSN/Other

  • ISSN: 2045-2322