The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Magnus Cinthio, MSc, PhD. Photo.

Magnus Cinthio

Senior lecturer

Magnus Cinthio, MSc, PhD. Photo.

Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow

Author

  • N. Bjarnegard
  • Eva Morsing
  • Magnus Cinthio
  • T. Lanne
  • Jana Brodszki

Summary, in English

Objectives To examine whether intrauterine growth restriction (IUGR) is associated with increased cardiovascular risk later in life. Methods We examined 19 young adults (aged 2225 years) who were born at term after IUGR, along with 18 controls. All had been examined previously with fetal Doppler, and in the present follow-up with echocardiography, carotid echo-tracking ultrasound, applanation tonometry, blood pressure and laser Doppler, in order to characterize their cardiac and vascular geometry and/or function. Results The diameter of the ascending aorta and the left ventricular diameter were smaller in the IUGR group, but only ascending aortic diameter remained significantly smaller after adjustment for body surface area (P<0.05). The aortic pressure augmentation index was higher in the IUGR group (P<0.05). The common carotid artery diameter, intimamedia thickness and distensibility as well as left ventricular mass and function were similar in the two groups. IUGR status was found to be an independent predictor of ascending aortic diameter. Conclusions IUGR due to placental dysfunction seems to contribute to the higher systolic blood pressure augmentation and the smaller aortic dimensions that are observed in adults more than 20 years later, with possible negative consequences for future left ventricular performance due to increased aortic impedance.

Department/s

  • Paediatrics (Lund)
  • Department of Biomedical Engineering
  • Obstetrics and Gynaecology (Lund)
  • EpiHealth: Epidemiology for Health

Publishing year

2013

Language

English

Pages

177-184

Publication/Series

Ultrasound in Obstetrics & Gynecology

Volume

41

Issue

2

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • aorta
  • echocardiography
  • intrauterine growth restriction
  • pulse wave
  • analysis
  • young adulthood

Status

Published

ISBN/ISSN/Other

  • ISSN: 1469-0705