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Magnus Cinthio, MSc, PhD. Photo.

Magnus Cinthio

Senior lecturer

Magnus Cinthio, MSc, PhD. Photo.

Normalization of Magnetic Field Effects: Towards Quantitative Magnetomotive Ultrasound Imaging

Author

  • Maria Evertsson
  • Magnus Cinthio
  • Sarah Fredriksson
  • Fredrik Olsson
  • Hans W Persson
  • Tomas Jansson

Summary, in English

In magnetomotive ultrasound (MMUS) imaging superparamagnetic iron oxide nanoparticles (NP) are used as contrast agents and a time-varying external magnetic field acts to move the particles and thereby the nanoparticle-laden tissue. Recently we proposed a frequency and phase sensitive algorithm to reduce motion artifacts. However, the method is not quantitative as the particle movement induced is dependent not only on the field strength, but also on the field gradient, plus material parameters. Here we assess the measured nanoparticle movement across the image plane in comparison with simulations of the magnetic force, to evaluate the potential for image normalization of magnetic field effects. We found that the movement decreased with distance to the iron core tip, from which the magnetic field was extending, and approaches zero at the transducer face. This finding did not coincide with the simulation and may make it difficult to enable quantification. The coefficient of variation between measurements on the homogeneous phantom was typically in the order of 15% for all frequencies, indicating the expected accuracy for quantitative measurements.

Department/s

  • Department of Biomedical Engineering

Publishing year

2012

Language

English

Pages

775-778

Publication/Series

2011 IEEE International Ultrasonics Symposium (IUS)

Document type

Conference paper

Publisher

IEEE - Institute of Electrical and Electronics Engineers Inc.

Topic

  • Medical Engineering

Keywords

  • multimodal imaging
  • molecular imaging
  • contrast agents
  • magnetic field
  • normalizations
  • quantitative measurements

Conference name

IEEE International Ultrasonics Symposium (IUS), 2011

Conference date

2011-10-18 - 2011-10-21

Conference place

Orlando, FL, United States

Status

Published

ISBN/ISSN/Other

  • ISBN: 978-1-4577-1253-1