Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging

Summary, in English

Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.

• Author: Roger Andersson; Maria Evertsson; Hanna Toftevall; Magnus Cinthio; Sarah Fredriksson; Tomas Jansson
• Department/s: Biomedical Engineering, Lund; Department of Biomedical Engineering
• Publishing year: 2016-11-01
• Language: English
• Publication/Series: 2016 IEEE International Ultrasonics Symposium, IUS 2016
• Volume: 2016-November
• Links: http://dx.doi.org/10.1109/ULTSYM.2016.7728380
• Document type: Conference paper
• Publisher: IEEE Computer Society
• Topic: Radiology, Nuclear Medicine and Medical Imaging
• Keywords: contrast agents; iron oxide; molecular imaging; nanoparticles; superparamagnetic
• Conference name: 2016 IEEE International Ultrasonics Symposium, IUS 2016
• Conference date: 2016-09-18 - 2016-09-21
• Conference place: Tours, France
• Status: Published
• ISBN/ISSN/Other: ISBN: 9781467398978