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Magdalena Naumovska, MD, PhD student. Photo.

Magdalena Naumovska

Research project participant

Magdalena Naumovska, MD, PhD student. Photo.

Mapping the architecture of the temporal artery with photoacoustic imaging for diagnosing giant cell arteritis

Author

  • Magdalena Naumovska
  • Aboma Merdasa
  • Björn Hammar
  • John Albinsson
  • Ulf Dahlstrand
  • Magnus Cinthio
  • Rafi Sheikh
  • Malin Malmsjö

Summary, in English

Photoacoustic (PA) imaging is rapidly emerging as a promising clinical diagnostic tool. One of the main applications of PA imaging is to image vascular networks in humans. This relies on the signal obtained from oxygenated and deoxygenated hemoglobin, which limits imaging of the vessel wall itself. Giant cell arteritis (GCA) is a treatable, but potentially sight- and life-threatening disease, in which the artery wall is infiltrated by leukocytes. Early intervention can prevent complications making prompt diagnosis of importance. Temporal artery biopsy is the gold standard for diagnosing GCA. We present an approach to imaging the temporal artery using multispectral PA imaging. Employing minimally supervised spectral analysis, we produce histology-like images where the artery wall is clearly discernible from the lumen and further differentiate between PA spectra from biopsies diagnosed as GCA- and GCA+ in 77 patients.

Department/s

  • Ophthalmology Imaging Research Group
  • Clinical research in neuro-ophthalmology
  • Ophthalmology, Lund
  • Department of Biomedical Engineering
  • LTH Profile Area: Engineering Health
  • Clinical and experimental lung transplantation
  • NPWT technology

Publishing year

2022-09-01

Language

English

Publication/Series

Photoacoustics

Volume

27

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology
  • Surgery

Keywords

  • Photoacoustic imaging
  • Giant cell arteritis
  • Unsupervised spectral analysis
  • Noninvasive, clinical diagnosis

Status

Published

Research group

  • Ophthalmology Imaging Research Group
  • Clinical research in neuro-ophthalmology
  • Clinical and experimental lung transplantation
  • NPWT technology

ISBN/ISSN/Other

  • ISSN: 2213-5979