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John Albinsson, MSc, PhD

John Albinsson

Research engineer

John Albinsson, MSc, PhD

Laser speckle contrast imaging enables perfusion monitoring of the anterior segment during strabismus surgery: a study on the horizontal rectus muscles

Author

  • Linn Engqvist
  • Rafi Sheikh
  • John Albinsson
  • Jonas Blohmé
  • Sandra Lindstedt
  • Ulf Dahlstrand

Summary, in English

Background A dreaded complication of strabismus surgery is anterior segment ischaemia (ASI), caused by damage to the anterior ciliary arteries. To avoid ASI, a maximum of two rectus muscles are operated on at a time. However, these surgical protocols are based on empirical observations of clinical outcome, rather than objective perfusion measurements. There is no method available for perioperative, real-time perfusion measurements during ocular muscle surgery. The aims of this study were to investigate whether laser speckle contrast imaging (LSCI) could be used for such measurements, and to monitor perfusion during strabismus surgery on one or two horizontal rectus muscles.Methods Forty-four eyes in 44 patients with horizontal strabismus underwent corrective surgery involving medial and/or lateral rectus muscle detachment. Perfusion in the adjacent paralimbal and iris tissue was monitored with LSCI.Results When the first horizontal rectus muscle was detached perfusion in the adjacent paralimbal tissue decreased by 23% (p<0.0001), and by 12% (p<0.0001) when the second muscle was detached. The iris perfusion decreased by 5% (p<0.05) when the first muscle was detached but showed no significant decrease as the second muscle was cut.Conclusion This is the first study showing that perfusion of the anterior segment can be monitored non-invasively with LSCI during strabismus surgery. In this cohort, two horizontal rectus muscles were detached with only a small decrease in the anterior segment circulation. Future studies are required for complete mapping of the effect of surgery on multiple ocular muscles on the anterior segment circulation.Data are available upon request.

Department/s

  • Ophthalmology, Lund
  • Ophthalmology Imaging Research Group
  • Clinical and experimental lung transplantation
  • LUCC: Lund University Cancer Centre
  • WCMM-Wallenberg Centre for Molecular Medicine
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • NPWT technology
  • DCD transplantation of lungs

Publishing year

2023

Language

English

Pages

1704-1708

Publication/Series

British Journal of Ophthalmology

Volume

107

Document type

Journal article

Publisher

BMJ Publishing Group

Topic

  • Ophthalmology

Status

Published

Research group

  • Ophthalmology Imaging Research Group
  • Clinical and experimental lung transplantation
  • NPWT technology
  • DCD transplantation of lungs

ISBN/ISSN/Other

  • ISSN: 1468-2079