
John Albinsson
Research engineer

Laser speckle contrast imaging enables perfusion monitoring of the anterior segment during strabismus surgery: a study on the horizontal rectus muscles
Author
Summary, in English
Background A dreaded complication of strabismus surgery is anterior segment ischaemia (ASI), caused by damage to the anterior ciliary arteries. To avoid ASI, a maximum of two rectus muscles are operated on at a time. However, these surgical protocols are based on empirical observations of clinical outcome, rather than objective perfusion measurements. There is no method available for perioperative, real-time perfusion measurements during ocular muscle surgery. The aims of this study were to investigate whether laser speckle contrast imaging (LSCI) could be used for such measurements, and to monitor perfusion during strabismus surgery on one or two horizontal rectus muscles.Methods Forty-four eyes in 44 patients with horizontal strabismus underwent corrective surgery involving medial and/or lateral rectus muscle detachment. Perfusion in the adjacent paralimbal and iris tissue was monitored with LSCI.Results When the first horizontal rectus muscle was detached perfusion in the adjacent paralimbal tissue decreased by 23% (p<0.0001), and by 12% (p<0.0001) when the second muscle was detached. The iris perfusion decreased by 5% (p<0.05) when the first muscle was detached but showed no significant decrease as the second muscle was cut.Conclusion This is the first study showing that perfusion of the anterior segment can be monitored non-invasively with LSCI during strabismus surgery. In this cohort, two horizontal rectus muscles were detached with only a small decrease in the anterior segment circulation. Future studies are required for complete mapping of the effect of surgery on multiple ocular muscles on the anterior segment circulation.Data are available upon request.
Department/s
- Ophthalmology, Lund
- Ophthalmology Imaging Research Group
- Clinical and experimental lung transplantation
- WCMM-Wallenberg Centre for Molecular Medicine
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- NPWT technology
- DCD transplantation of lungs
Publishing year
2023
Language
English
Pages
1704-1708
Publication/Series
British Journal of Ophthalmology
Volume
107
Document type
Journal article
Publisher
BMJ Publishing Group
Topic
- Ophthalmology
Status
Published
Research group
- Ophthalmology Imaging Research Group
- Clinical and experimental lung transplantation
- NPWT technology
- DCD transplantation of lungs
ISBN/ISSN/Other
- ISSN: 1468-2079