Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.

Summary, in English

Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.

• Author: Viktor Hamrefors; Bo Hedblad; George Hindy; Gustav Smith; Peter Almgren; Gunnar Engström; Marketa Sjögren; Klas Gränsbo; Marju Orho-Melander; Olle Melander
• Department/s: Cardiovascular Research - Hypertension; Cardiovascular Research - Epidemiology; Diabetes - Cardiovascular Disease; Cardiology; Translational Muscle Research; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publishing year: 2014
• Language: English
• Publication/Series: PLoS ONE
• Volume: 9
• Issue: 1
• Full text: - 505 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24465769?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0085893
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Endocrinology and Diabetes; Cardiac and Cardiovascular Systems
• Status: Published
• Research group: Cardiovascular Research - Hypertension; Cardiovascular Research - Epidemiology; Diabetes - Cardiovascular Disease; Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Other: ISSN: 1932-6203