Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.

Summary, in English

Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy.

• Author: Jessica L Mega; Nathan O Stitziel; Gustav Smith; Daniel I Chasman; Mark J Caulfield; James J Devlin; Francesco Nordio; Craig L Hyde; Christopher P Cannon; Frank M Sacks; Neil R Poulter; Peter S Sever; Paul M Ridker; Eugene Braunwald; Olle Melander; Sekar Kathiresan; Marc S Sabatine
• Department/s: Cardiology; Cardiovascular Research - Hypertension; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publishing year: 2015
• Language: English
• Pages: 2264-2271
• Publication/Series: The Lancet
• Volume: 385
• Issue: 9984
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25748612?dopt=Abstract; http://dx.doi.org/10.1016/S0140-6736(14)61730-X
• Document type: Journal article
• Publisher: Elsevier
• Topic: Cardiac and Cardiovascular Systems
• Status: Published
• Research group: Cardiovascular Research - Hypertension
• ISBN/ISSN/Other: ISSN: 1474-547X