Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.

Summary, in English

Atrial fibrillation (AF) is prevalent and there is a clinical need for biomarkers to identify individuals at higher risk for AF. Fixed throughout a life course and assayable early in life, genetic biomarkers may meet this need. Here, we investigate whether multiple single nucleotide polymorphisms together as an AF genetic risk score (AF-GRS) can improve prediction of one's risk for AF.

• Author: Hayato Tada; Dov Shiffman; Gustav Smith; Marketa Sjögren; Steven A Lubitz; Patrick T Ellinor; Judy Z Louie; Joseph J Catanese; Gunnar Engström; James J Devlin; Sekar Kathiresan; Olle Melander
• Department/s: Cardiology; Cardiovascular Research - Hypertension; Cardiovascular Research - Epidemiology; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publishing year: 2014
• Language: English
• Pages: 2856-2856
• Publication/Series: Stroke: a journal of cerebral circulation
• Volume: 45
• Issue: 10
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25123217?dopt=Abstract; http://dx.doi.org/10.1161/STROKEAHA.114.006072
• Document type: Journal article
• Publisher: American Heart Association
• Topic: Neurology
• Status: Published
• Research group: Cardiovascular Research - Hypertension; Cardiovascular Research - Epidemiology
• ISBN/ISSN/Other: ISSN: 1524-4628