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Gustav Smith, MD, PhD

Gustav Smith

Associate professor

Gustav Smith, MD, PhD

The relationships between the plasma metabolome and orthostatic blood pressure responses

Author

  • Christian Zambach
  • Jingxue Pan
  • Sofia Gerward
  • Artur Fedorowski
  • J Gustav Smith
  • Gunnar Engström
  • Viktor Hamrefors

Summary, in English

Whereas autonomic dysfunction and the metabolic syndrome are clinically associated, the relationships with the plasma metabolome is unknown. We explored the association between orthostatic blood pressure responses and 818 plasma metabolites in middle-aged subjects from the general population. We included 3803 out of 6251 subjects (mean age, 57 years; 52% women) from the Malmö sub-cohort of The Swedish CardioPulmonary bioImage Study with information on smoking habits, diabetes, antihypertensive drug treatment, anthropometrics, hemodynamic measurements and 818 plasma metabolites (mass-spectrometry). The associations between each metabolite and orthostatic systolic blood pressure responses were determined using multivariable linear regression analysis and p values were corrected using the Bonferroni method. Six amino acids, five vitamins, co-factors and carbohydrates, nine lipids and two xenobiotics were associated with orthostatic blood pressure after adjusting for age, gender and systolic blood pressure. After additional adjustments for BMI, diabetes, smoking and antihypertensive treatment, the association remained significant for six lipids, four amino acids and one xenobiotic. Twenty-two out of 818 plasma metabolites were associated with orthostatic blood pressure responses. Eleven metabolites, including lipids in the dihydrosphingomyelin and sphingosine pathways, were independently associated with orthostatic systolic blood pressure responses after additional adjustment for markers of cardio-metabolic disease.

Department/s

  • Department of Clinical Sciences, Malmö
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • WCMM-Wallenberg Centre for Molecular Medicine
  • Cardiology
  • EpiHealth: Epidemiology for Health
  • Department of Clinical Sciences, Lund

Publishing year

2023-10-25

Language

English

Publication/Series

Scientific Reports

Volume

13

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • Middle Aged
  • Humans
  • Female
  • Male
  • Blood Pressure/physiology
  • Hypotension, Orthostatic
  • Antihypertensive Agents/pharmacology
  • Diabetes Mellitus
  • Metabolome
  • Amino Acids/pharmacology
  • Lipids/pharmacology

Status

Published

Research group

  • LUDC (Lund University Diabetes Centre)

ISBN/ISSN/Other

  • ISSN: 2045-2322