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Gustav Smith, MD, PhD

Gustav Smith

Associate professor

Gustav Smith, MD, PhD

Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS

Author

  • Gabriel Baldanzi
  • Sergi Sayols-Baixeras
  • Elin Ekblom-Bak
  • Örjan Ekblom
  • Koen F. Dekkers
  • Ulf Hammar
  • Diem Nguyen
  • Shafqat Ahmad
  • Ulrika Ericson
  • Daniel Arvidsson
  • Mats Börjesson
  • Peter J. Johanson
  • J. Gustav Smith
  • Göran Bergström
  • Lars Lind
  • Gunnar Engström
  • Johan Ärnlöv
  • Beatrice Kennedy
  • Marju Orho-Melander
  • Tove Fall
Show all

Summary, in English

Background: Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), and vigorous-intensity (VPA) physical activity with the gut microbiota using cross-sectional data from the Swedish CArdioPulmonary bioImage Study. Methods: In 8416 participants aged 50–65, time in SED, MPA, and VPA were estimated with hip-worn accelerometer. Gut microbiota was profiled using shotgun metagenomics of faecal samples. We applied multivariable regression models, adjusting for sociodemographic, lifestyle, and technical covariates, and accounted for multiple testing. Findings: Overall, associations between time in SED and microbiota species abundance were in opposite direction to those for MPA or VPA. For example, MPA was associated with lower, while SED with higher abundance of Escherichia coli. MPA and VPA were associated with higher abundance of the butyrate-producers Faecalibacterium prausnitzii and Roseburia spp. We observed discrepancies between specific VPA and MPA associations, such as a positive association between MPA and Prevotella copri, while no association was detected for VPA. Additionally, SED, MPA and VPA were associated with the functional potential of the microbiome. For instance, MPA was associated with higher capacity for acetate synthesis and SED with lower carbohydrate degradation capacity. Interpretation: Our findings suggest that sedentary and physical activity are associated with a similar set of gut microbiota species but in opposite directions. Furthermore, the intensity of physical activity may have specific effects on certain gut microbiota species. Funding: European Research Council, Swedish Heart-Lung Foundation, Swedish Research Council, Knut and Alice Wallenberg Foundation.

Department/s

  • Diabetes - Cardiovascular Disease
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • WCMM-Wallenberg Centre for Molecular Medicine
  • Molecular Epidemiology and Cardiology
  • Cardiovascular Research - Epidemiology

Publishing year

2024

Language

English

Publication/Series

EBioMedicine

Volume

100

Document type

Journal article

Publisher

Elsevier

Topic

  • Environmental Health and Occupational Health

Keywords

  • Accelerometery
  • Epidemiology
  • Exercise
  • Gastrointestinal microbiome
  • Sedentary behaviour

Status

Published

Research group

  • Diabetes - Cardiovascular Disease
  • Molecular Epidemiology and Cardiology
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 2352-3964