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Gustav Smith, MD, PhD

Gustav Smith

Associate professor

Gustav Smith, MD, PhD

Profiling of the plasma proteome across different stages of human heart failure

Author

  • Anna Egerstedt
  • John Berntsson
  • Maya Landenhed Smith
  • Olof Gidlöf
  • Roland Nilsson
  • Mark Benson
  • Quinn S. Wells
  • Selvi Celik
  • Carl Lejonberg
  • Laurie Farrell
  • Sumita Sinha
  • Dongxiao Shen
  • Jakob Lundgren
  • Göran Rådegran
  • Debby Ngo
  • Gunnar Engström
  • Qiong Yang
  • Thomas J. Wang
  • Robert E. Gerszten
  • J. Gustav Smith
Show all

Summary, in English

Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF incidence in a population-based cohort, implicating modulation of immunological, complement, coagulation, natriuretic and matrix remodeling pathways up to two decades prior to overt disease onset. We observe further divergence of these proteins from the general population in advanced HF, and regression after heart transplantation. By leveraging coronary sinus samples and transcriptomic tools, we describe likely cardiac and specific cellular origins for several of the proteins, including Nt-proBNP, thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5. Our findings provide a broad perspective on both cardiac and systemic factors associated with HF development.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Molecular Epidemiology and Cardiology
  • Cardiovascular Research - Epidemiology
  • Artificial Intelligence in CardioThoracic Sciences (AICTS)
  • Cardiovascular Epigenetics
  • Lund Hemodynamic Lab
  • EpiHealth: Epidemiology for Health
  • WCMM-Wallenberg Centre for Molecular Medicine

Publishing year

2019

Language

English

Publication/Series

Nature Communications

Volume

10

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Molecular Epidemiology and Cardiology
  • Cardiovascular Research - Epidemiology
  • Artificial Intelligence in CardioThoracic Sciences (AICTS)
  • Cardiovascular Epigenetics
  • Lund Hemodynamic Lab

ISBN/ISSN/Other

  • ISSN: 2041-1723