Gustav Smith
Associate professor
Subsequent Event Risk in Individuals With Established Coronary Heart Disease
Author
Summary, in English
BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
Department/s
- Cardiovascular Research - Hypertension
- Diabetes - Cardiovascular Disease
- EXODIAB: Excellence of Diabetes Research in Sweden
- Cardiology
- Heart Failure and Mechanical Support
- EpiHealth: Epidemiology for Health
- Molecular Epidemiology and Cardiology
Publishing year
2019-03-21
Language
English
Pages
145-160
Publication/Series
Circulation: Genomic and Precision Medicine
Volume
12
Issue
4
Document type
Journal article
Publisher
Lippincott Williams & Wilkins
Topic
- Cardiac and Cardiovascular Systems
Keywords
- coronary artery disease
- genetics
- myocardial infarction
- prognosis
- secondary prevention
Status
Published
Research group
- Cardiovascular Research - Hypertension
- Diabetes - Cardiovascular Disease
- Heart Failure and Mechanical Support
- Molecular Epidemiology and Cardiology
ISBN/ISSN/Other
- ISSN: 2574-8300