Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Summary, in English

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

• Author: Gustav Smith; Kevin Luk; Christina-Alexandra Schulz; James C Engert; Ron Do; George Hindy; Gull Rukh; Line Dufresne; Peter Almgren; David S Owens; Tamara B Harris; Gina M Peloso; Kathleen F Kerr; Quenna Wong; Albert V Smith; Matthew J Budoff; Jerome I Rotter; L Adrienne Cupples; Stephen Rich; Sekar Kathiresan; Marju Orho-Melander; Vilmundur Gudnason; Christopher J O'Donnell; Wendy S Post; George Thanassoulis
• Department/s: Cardiology; Diabetes - Cardiovascular Disease; Translational Muscle Research; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publishing year: 2014
• Language: English
• Pages: 1764-1771
• Publication/Series: JAMA: The Journal of the American Medical Association
• Volume: 312
• Issue: 17
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25344734?dopt=Abstract; http://dx.doi.org/10.1001/jama.2014.13959
• Document type: Journal article
• Publisher: American Medical Association
• Topic: Endocrinology and Diabetes
• Status: Published
• Research group: Diabetes - Cardiovascular Disease; Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Other: ISSN: 1538-3598