The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Bodil Gesslein, MSc, PhD. Photo.

Bodil Gesslein

Visiting research fellow

Bodil Gesslein, MSc, PhD. Photo.

Evaluation of continuous and intermittent myocardial topical negative pressure.

Author

  • Sandra Lindstedt Ingemansson
  • Malin Malmsjö
  • Bodil Gesslein
  • Richard Ingemansson

Summary, in English

OBJECTIVE: Topical negative pressure, commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in subcutaneous tissue and skeletal muscle. In wound therapy, intermittent negative pressure is often preferred to continuous negative pressure as tissue exposed to intermittent therapy shows twice as much granulation tissue formation than that exposed to continuous pressure after 2 weeks of therapy. The present study was designed to elucidate the differences in microvascular blood flow in the left anterior descending artery area between continuous and intermittent myocardial topical negative pressure of -50 mmHg. METHODS: Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally into the heart muscle in the left anterior descending artery area at depths of approximately 5-6 mm. Measurements of microvascular blood flow were performed in normal myocardium and ischemic myocardium during 20 min of countinuous and intermittent topical negative pressure at -50 mmHg. RESULTS: Both continuous and intermittent topical negative pressure of -50 mmHg significantly increased microvascular blood flow in the underlying myocardium: from 56.2 +/- 13.1 perfusion units (PU) before to 132.8 +/- 7.4 PU during countinuous topical negative pressure application (P < 0.05) and from 75.8 +/- 12.1 PU before to 153.6 +/- 4.7 PU during intermittent topical negative pressure application (P < 0.05). CONCLUSION: No statistically significant difference was found between microvascular blood flow during 20 min of continuous and intermittent topical negative pressure at -50 mmHg in this porcine model.

Department/s

  • Thoracic Surgery
  • Medicine, Lund

Publishing year

2008

Language

English

Pages

813-819

Publication/Series

Journal of Cardiovascular Medicine

Volume

9

Issue

8

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Other Clinical Medicine
  • Cardiac and Cardiovascular Systems
  • Surgery

Status

Published

ISBN/ISSN/Other

  • ISSN: 1558-2027