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Associate Professor Sophia Zackrisson, MD, PhD. Photo.

Sophia Zackrisson

Manager

Associate Professor Sophia Zackrisson, MD, PhD. Photo.

Methodology to simulate temporal changes in breast tumors and parenchyma using Perlin noise

Author

  • Hanna Tomic
  • Pontus Timberg
  • John Henry Markbo
  • Sophia Zackrisson
  • Anders Tingberg
  • Magnus Dustler
  • Predrag R. Bakic

Editor

  • John M. Sabol
  • Ke Li
  • Shiva Abbaszadeh

Summary, in English

Simulating temporal changes in breast tissue has been challenging, despite advancement in virtual clinical trials. This study aims to enable virtual trials over time, motivated by interest in the effect of tissue involution on tumor visibility. We present a framework for creating 3D voxel-based breast phantoms and lesions using in-house Perlin Noise-based algorithm. The framework consists of three modules “Population Creator”, “Phantom Creator” and “Lesion Creator”. Population Creator generates a population based on characteristics from real clinical cases. Phantom and Lesion Creator enable selection of breast shape, size, density, and lesion shape and size. Perlin Noise parameters are selected to match the appearance of different tissue types. We used open-source software to reconstruct digital breast tomosynthesis images. Alternative software can be used for other imaging modalities. We illustrate the use of the framework to simulate temporal changes in the breast. First, assuming that the average volumetric breast density is 10.7% at 57 years of age and decreases exponentially over time, we create the phantom at the start and the end of the screening program (40 and 74 years, respectively, in Sweden). The breast density was calculated as 16.0% and 7.2%, respectively. Second, we show a simulated lesion at different time points, assuming a tumour volume doubling time of 282 days. We present a simulation framework for temporal changes in breast anatomy. We illustrate two applications which support the use of virtual clinical trials over time.

Department/s

  • Diagnostic Radiology, (Lund)
  • Radiology Diagnostics, Malmö
  • Medical Radiation Physics, Malmö
  • LUCC: Lund University Cancer Centre
  • Medical Radiation Physics, Lund
  • Department of Translational Medicine
  • EpiHealth: Epidemiology for Health
  • LTH Profile Area: Photon Science and Technology
  • LU Profile Area: Light and Materials

Publishing year

2025

Language

English

Publication/Series

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volume

13405

Document type

Conference paper

Publisher

SPIE

Topic

  • Radiology and Medical Imaging

Keywords

  • breast density
  • Breast phantoms
  • breast tumors
  • computer simulation
  • temporal changes in anatomy
  • virtual clinical trials

Conference name

Medical Imaging 2025: Physics of Medical Imaging

Conference date

2025-02-17 - 2025-02-21

Conference place

San Diego, United States

Status

Published

Research group

  • Radiology Diagnostics, Malmö
  • Medical Radiation Physics, Malmö

ISBN/ISSN/Other

  • ISBN: 9781510685888