Nina Reistad
Senior lecturer
Resorbable optical fibers for interstitial photodynamic therapy - assessment of photosensitizer spatial distribution in tumors
Author
Summary, in English
Significance: Optical-quality bioresorbable implants, which gradually dissolve within the body, are gaining increasing interest due to their potential to eliminate the need for revision surgeries. These implants show significant promise in treating deep-seated tumors in high-risk areas, such as the brain, and offer extended capabilities for monitoring interstitial physiological parameters or pharmacokinetics through photonic technologies.
Aim: A proof-of-principle validation has been conducted on calcium phosphate glass (CPG)-based bioresorbable optical fibers to assess their capability to monitor the spatial distribution of photosensitizing (PS) drugs in tumors - an essential parameter to optimize for enhanced treatment outcomes in photodynamic therapy (PDT).
Approach: Ex vivo validation was performed on liquid phantoms with solid tumor-mimicking inclusions containing the fluorescent PS drug. In-house developed bioresorbable fibers, with optical characteristics similar to silica fibers used in current PDT systems, were utilized. For the first time, these fibers were used for the interstitial acquisition of fluorescent signals, followed by the tomographic reconstruction of the drug distribution in the phantom. The results were compared with those obtained from a standard clinical system equipped with silica fibers.
Results: The reconstructed drug distribution with bioresorbable fibers agreed with that obtained using the same system with standard silica fibers.
Conclusions: We reveal the potential of further exploring CPG bioresorbable optical fibers for interstitial PDT.
Aim: A proof-of-principle validation has been conducted on calcium phosphate glass (CPG)-based bioresorbable optical fibers to assess their capability to monitor the spatial distribution of photosensitizing (PS) drugs in tumors - an essential parameter to optimize for enhanced treatment outcomes in photodynamic therapy (PDT).
Approach: Ex vivo validation was performed on liquid phantoms with solid tumor-mimicking inclusions containing the fluorescent PS drug. In-house developed bioresorbable fibers, with optical characteristics similar to silica fibers used in current PDT systems, were utilized. For the first time, these fibers were used for the interstitial acquisition of fluorescent signals, followed by the tomographic reconstruction of the drug distribution in the phantom. The results were compared with those obtained from a standard clinical system equipped with silica fibers.
Results: The reconstructed drug distribution with bioresorbable fibers agreed with that obtained using the same system with standard silica fibers.
Conclusions: We reveal the potential of further exploring CPG bioresorbable optical fibers for interstitial PDT.
Department/s
- LU Profile Area: Light and Materials
- LTH Profile Area: Engineering Health
- Atomic Physics
- LUCC: Lund University Cancer Centre
- LTH Profile Area: Photon Science and Technology
Publishing year
2025-05-14
Language
English
Publication/Series
Journal of Biomedical Optics
Volume
30
Issue
5
Document type
Journal article
Publisher
SPIE
Topic
- Atom and Molecular Physics and Optics
- Medical Biotechnology
Keywords
- photodynamic therapy
- bioresorbable photonics
- photosensitizer distribution
- optical fibers
- diffuse optical tomography
- fluorescence
Status
Published
ISBN/ISSN/Other
- ISSN: 1560-2281