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Professor Malin Malmsjö, MD, PhD. Photo.

Malin Malmsjö

Professor

Professor Malin Malmsjö, MD, PhD. Photo.

Two photoacoustic spectral coloring compensation techniques adapted to the context of human in-vivo oxygenation measurements

Author

  • Azin Khodaverdi
  • Baptiste Jayet
  • Tobias Erlöv
  • John Albinsson
  • Aboma Merdasa
  • Nils Gustafsson
  • Rafi Sheikh
  • Malin Malmsjö
  • Stefan Andersson-Engels
  • Magnus Cinthio

Summary, in English

Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation on in-vivo human data. Both methods have been modified and adapted to this context. The first modified method was evaluated using a tissue-mimicking phantom, showing restoration of the original spectrum of the target and decreasing the relative mean square error from 65% to 1.2% for the highest concentration. Spatial maps of sO2 were estimated from in-vivo human finger measurements using both methods and compared with linear unmixing. Both methods reconstructed comparable values of sO2 and reduced depth-dependent changes in sO2, typically seen with linear unmixing, resulting in a gradient of saturation closer to zero as expected physiologically.

Department/s

  • LU Profile Area: Light and Materials
  • LTH Profile Area: Engineering Health
  • Division for Biomedical Engineering
  • LTH Profile Area: Photon Science and Technology
  • Ophthalmology Imaging Research Group
  • Solid State Physics
  • LTH Profile Area: Nanoscience and Semiconductor Technology
  • NanoLund: Centre for Nanoscience
  • Clinical and experimental lung transplantation
  • NPWT technology
  • Biomedical Engineering (M.Sc.Eng.)

Publishing year

2025-06-01

Language

English

Pages

2217-2231

Publication/Series

Biomedical Optics Express

Volume

16

Issue

6

Document type

Journal article

Publisher

Optical Society of America

Topic

  • Medical Laboratory Technologies
  • Ophthalmology

Status

Published

Research group

  • Ophthalmology Imaging Research Group
  • Clinical and experimental lung transplantation
  • NPWT technology

ISBN/ISSN/Other

  • ISSN: 2156-7085