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Magdalena Naumovska, MD, PhD. Photo.

Magdalena Naumovska

Research project participant

Magdalena Naumovska, MD, PhD. Photo.

High prevalence of androgen deficiency and abnormal lipid profile in infertile men with non-obstructive azoospermia.

Author

  • Johannes Bobjer
  • Naumovska M
  • Yvonne Lundberg Giwercman
  • Aleksander Giwercman

Summary, in English

In men with non-obstructive azoospermia (NOA), the risk of hypogonadism is often overlooked. Testicular sperm extraction (TESE) may increase this risk. The objective of this study was to elucidate the prevalence of hypogonadism in NOA-patients, the impact of TESE on hormone balance and the association between testosterone deficiency and dyslipidaemia. Men with NOA who had undergone TESE during the period 2004-2009 were eligible. Hypogonadism was defined as total testosterone <10 nmol/L and/or LH >10 IU/L and/or ongoing androgen replacement therapy. Sixty-five consecutive men who had undergone TESE owing to NOA and from whom post-TESE serum testosterone levels measured before 1100 h were available. Furthermore, 141 fertile men served as controls. Serum concentrations of testosterone, LH and lipids were assessed. Odds ratios (OR) for biochemical hypogonadism were calculated. Pre- and post-TESE hormone levels were compared. Lipid profile was related to testosterone levels. Hypogonadism was found in 47% (95% CI, 0.36, 0.59) of the NOA-men. As compared with fertile controls, the OR for hypogonadism post-TESE was 17 (95% CI 6.6-45). Serum LH (p = 0.03), but not testosterone (p = 0.43), differed significantly pre- and post-TESE. Compared with eugonadal NOA-men, the OR for having deviations in lipid profile was 3.3 (95% CI 1.3-8.8) for the hypogonadal NOA-men. NOA-men are at very high risk of androgen deficiency, which even in young subjects is associated with dyslipidaemia. Medical management of these men should therefore include endocrinological evaluation and follow-up after completion of infertility treatment.

Department/s

  • Reproductive medicine, Malmö
  • EpiHealth: Epidemiology for Health
  • Molecular genetic reproductive medicine, Malmö

Publishing year

2012

Language

English

Pages

688-694

Publication/Series

International Journal of Andrology

Volume

35

Issue

5

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Gynaecology, Obstetrics and Reproductive Medicine

Status

Published

Research group

  • Reproductive medicine, Malmö
  • Molecular genetic reproductive medicine, Malmö

ISBN/ISSN/Other

  • ISSN: 1365-2605